Neurotransmitters are important chemical messengers in the nervous system that play a crucial role in physiological and physical health. Abnormal levels of neurotransmitters have been correlated with physical, psychotic, and neurodegenerative diseases such as Alzheimer’s, Parkinson’s, dementia, addiction, depression, and schizophrenia. Although multiple neurotechnological approaches have been reported in the literature, the detection and monitoring of neurotransmitters in the brain remains a challenge and continues to garner significant attention. Neurotechnology that provides high-throughput, as well as fast and specific quantification of target analytes in the brain, without negatively impacting the implanted region is highly desired for the monitoring of the complex intercommunication of neurotransmitters. Therefore, it is crucial to develop clinical assessment techniques that are sensitive and reliable to monitor and modulate these chemical messengers and screen diseases. This r.
Download Free PDF View PDF
Neurotransmitters are endogenous chemical messengers which play an important role in many of the brain functions, abnormal levels being correlated with physical, psychotic and neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's disease. Therefore, their sensitive and robust detection is of great clinical significance. Electrochemical methods have been intensively used in the last decades for neurotransmitter detection, outclassing more complicated analytical techniques such as conventional spectrophotometry, chromatography, fluorescence, flow injection, and capillary electrophoresis. In this manuscript, the most successful and promising electrochemical enzyme-free and enzymatic sensors for neurotransmitter detection are reviewed. Focusing on the activity of worldwide researchers mainly during the last ten years (2010–2019), without pretending to be exhaustive, we present an overview of the progress made in sensing strategies during this time. Pa.
Download Free PDF View PDF
Abstrac t Biosensors are devices that detect and transmit information regarding a physiological change or the presence of various chemical or biological materials in a given environment. A new concept of electrochemical biosensors, directly related to the biological redox processes at the cellular and subcellular level, is proposed for testing microfluidic probes, in order to investigate and treat neurological disorders. The micro-electrode features at nanoscale are based on incorporating via electropolymerization of oxidized conductive conjugated polymers at the surface of carbon structures with predefined architectures at nano-scale. The electrochemical characterization of novel micro-electrodes was performed by using reference redox molecules. The final sensorial features regarded the concept sensitivity and reproducibility at different concentrations of dopamine, epinephrine and norepinephrine in acid medium (0.1 M HCl). In order to tailor the hybrid bio-sensors for extended med.
Download Free PDF View PDF
IEEE Engineering in Medicine and Biology Magazine
Download Free PDF View PDF
